Ipamorelin (10mg vials)

Ipamorelin

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Peptide Partners Manufacturer Id: WF03

Batch Id: IP202601

Research Studies

(for educational purposes only)

Study 1: Ipamorelin, the first selective growth hormone secretagogue

Authors: K Raun, B S Hansen, N L Johansen, H Thøgersen, K Madsen, M Ankersen, P H Andersen

Source: https://pubmed.ncbi.nlm.nih.gov/9849822/

Scientific Findings

In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (EC50 = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH.

Plain English Interpretation

Scientists have developed a new compound called ipamorelin that can stimulate the release of growth hormone (GH). In laboratory experiments using rat pituitary cells, ipamorelin was found to be as effective as a similar compound, GHRP-6, in releasing GH. The study also showed that ipamorelin works by activating a specific receptor in the pituitary gland. Unlike other similar compounds, ipamorelin is very selective and does not cause the release of other hormones like cortisol or ACTH, which are stress-related hormones. This makes ipamorelin a promising candidate for future clinical use as a safe and effective way to boost growth hormone levels.

Study 2: The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus

Authors: Mallikarjun Gouda, C.B. Ganesh

Source: https://www.sciencedirect.com/science/article/pii/S0378432024001416

Scientific Findings

The administration of either 5 or 30 µg of IPA for 21 days led to a significant and dose-dependent rise in food intake concomitant with a significant increase in the numbers of primary spermatocytes, secondary spermatocytes, and early spermatids compared to the control group. There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 µg of IPA, compared to the control group. Moreover, there was no significant difference in the percentage of gonadotropin-releasing hormone (GnRH)-immunoreactive fibres in the hypothalamus and anterior pituitary gland across different groups. However, a significant elevation in the expression of androgen receptor protein was observed in fish treated with 30 µg of IPA. Furthermore, the concentrations of luteinizing hormone (LH) and 11-ketotestosterone (11-KT) in the serum of fish treated with either 5 or 30 µg of IPA were significantly elevated in comparison to the control group. Collectively, these findings suggest that the administration of ghrelin enhances the development of germ cells during the meiosis-I phase and that this effect might be mediated via the stimulation of 11-KT and androgen receptors at the testicular level and LH at the pituitary level in the tilapia.

Plain English Interpretation

In a study on tilapia fish, researchers found that giving them a substance called ipamorelin acetate (IPA) for 21 days made them eat more and produced more sperm cells. The fish that got a higher dose of IPA had more mature sperm and larger reproductive tissues. While the treatment didn’t change the levels of a key reproductive hormone in the brain, it did increase the levels of another hormone that stimulates testosterone production. This suggests that ipamorelin helps to improve fertility in fish by boosting sperm development through a complex hormonal process.

Study 3: Detection of the synthetic peptide ipamorelin in dried blood spots by means of UHPLC-HRMS

Authors: Enrico Gerace, Jessica Modaffari, Pierre Negri, Daniele Di Corcia, Eleonora Amante, Alberto Salomone, Marco Vincenti

Source: https://www.sciencedirect.com/science/article/abs/pii/S1387380621000117

Scientific Findings

A simple and effective procedure based on a fast methanolic extraction and a LC-HRMS detection of the growth hormone secretagogue ipamorelin in DBS was recently proposed by Gerace et al. [193]. MS and MS/MS data were collected by a Q-TOF mass spectrometer operating in the positive ESI mode.

Plain English Interpretation

Researchers have developed a new method to detect the synthetic peptide ipamorelin in dried blood spots. This method is simple, fast, and effective. It uses a technique called liquid chromatography-high resolution mass spectrometry (LC-HRMS) to identify and measure the amount of ipamorelin in the blood sample. This new method could be useful for a variety of applications, including monitoring the use of ipamorelin in athletes.

⚠️ Research Use Only: This product is intended for research purposes only. Not for human consumption. Not approved by the FDA. For use by qualified researchers only. Keep out of reach of children.