{"product_id":"humanin-10mg-vials","title":"Humanin (10mg vials)","description":"\u003cp\u003e\u003cstrong\u003eHumanin\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch4\u003e\u003cbr\u003e\u003c\/h4\u003e\n\u003ch5\u003eSave over 60%!\u003c\/h5\u003e\n\u003cp\u003eSwipe right to view full table →\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003ch5\u003eCost per milligram\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003ch5\u003e\u003cstrong\u003e$6.60 – $8.25\u003c\/strong\u003e\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003ch5\u003ePurity\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003ch5\u003e\u003cstrong\u003e99.92%\u003c\/strong\u003e\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003ch5\u003eCertified Endotoxin-safe\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003ch5\u003e\u003cstrong\u003eYes\u003c\/strong\u003e\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003ch5\u003eIndependently Tested\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003ch5\u003e\u003cstrong\u003eYes\u003c\/strong\u003e\u003c\/h5\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003ePeptide Partners Manufacturer Id\u003c\/strong\u003e: WF03\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBatch Id\u003c\/strong\u003e:  HP20250805\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eResearch Studies\u003c\/h3\u003e\n\u003ch6\u003e(for educational purposes only)\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 class=\"MdHeading3\"\u003eStudy 1: Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progression\u003c\/h4\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eAuthors\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eCuong P. Ha, Tuyen N. M. Hua, Vu. T. A. Vo, Jiyeon Om, Sangwon Han, Seung-Kuy Cha, Kyu-Sang Park \u0026amp; Yangsik Jeong\u003c\/p\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eSource\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"MdLink\"\u003ehttps:\/\/www.nature.com\/articles\/s41419-024-06790-8\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003eScientific Findings\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThe study investigates the role of the mitochondria-derived peptide humanin in glioblastoma progression. It demonstrates that humanin is highly expressed in glioblastoma tissues and can induce glioblastoma stem cell (GSC) attachment, filopodia formation, and migration through direct binding to integrin αVβ8. Humanin activates the integrin αV–TGFβ signaling axis, leading to canonical TGFβ pathway activation, promoting tumor cell invasion, angiogenesis, and overall tumor aggressiveness. The research combines in silico, in vitro, and in vivo approaches, showing that humanin facilitates glioblastoma progression via integrin-mediated cell adhesion and subsequent TGFβ signaling, ultimately contributing to poorer prognosis. Targeting the humanin–integrin–TGFβ axis may offer therapeutic potential.\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003ePlain English Interpretation\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThis study shows that a small protein called humanin, made inside the mitochondria, helps brain cancer cells stick together and move around more easily, making the cancer more aggressive. Humanin binds directly to a specific receptor on the cancer cells called integrin αVβ8, which then turns on a signaling pathway involving TGFβ that encourages the cancer to invade nearby tissues and grow new blood vessels. These findings suggest that blocking humanin or its interaction with these receptors could be a new way to treat this deadly brain cancer.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 class=\"MdHeading3\"\u003eStudy 2: Humanin variants aggregate to produce different fibril morphologies\u003c\/h4\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eAuthors\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eDaniel L. Morris, Sarah B. Nyenhuis, James M. Gruschus, David A. Nyenhuis, Rashmi Puja, Jenny E. Hinshaw, Nico Tjandra\u003c\/p\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eSource\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"MdLink\"\u003ehttps:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925825022537\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003eScientific Findings\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThis study investigates the fibrillization of Humanin (HN) and its variants using transmission electron microscopy and other biophysical techniques. The research demonstrates that HN forms amyloid-like β-sheet fibrils and that specific mutations can inhibit this process. These mutations are linked to secretion deficiencies in vitro, emphasizing the role of β-sheet structures in membrane interactions. The study also highlights that these structural transitions are necessary for HN to interact with BCL-2 family proteins and inhibit apoptosis, suggesting that the fibrillization of HN is a key aspect of its cytoprotective function.\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003ePlain English Interpretation\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThis research explores how the small protein Humanin clumps together to form fibers, similar to those seen in some diseases. By creating different versions of Humanin, the scientists found that the protein’s ability to form these fibers is crucial for its protective effects against cell death. The study suggests that the shape and structure of Humanin are essential for it to work correctly, particularly in how it interacts with cell membranes and other proteins involved in cell survival.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 class=\"MdHeading3\"\u003eStudy 3: The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction\u003c\/h4\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eAuthors\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eParameswaran G Sreekumar, Keijiro Ishikawa, Chris Spee, Hemal H Mehta, Junxiang Wan, Kelvin Yen, Pinchas Cohen, Ram Kannan, David R Hinton\u003c\/p\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan class=\"MdStrong\"\u003e\u003cspan\u003e\u003cstrong\u003eSource\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"MdLink\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4811181\/\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003eScientific Findings\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThe study investigates the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effects on oxidative stress–induced cell death, mitochondrial bioenergetics, and senescence. Humanin localizes to cytoplasmic and mitochondrial compartments in RPE cells. Exogenous HN is taken up by RPE cells, colocalizing with mitochondria, and inhibits reactive oxygen species formation, restoring mitochondrial bioenergetics. HN increases mitochondrial DNA copy number, upregulates mitochondrial biogenesis regulator mtTFA, and protects RPE cells from oxidative stress–induced apoptosis and senescence. It also maintains transepithelial resistance in polarized RPE monolayers under oxidative stress. The data suggest HN could be a potential therapeutic agent for retinal degeneration including AMD.\u003c\/p\u003e\n\u003ch5 class=\"MdHeading4\"\u003ePlain English Interpretation\u003c\/h5\u003e\n\u003cp class=\"MdParagraph\"\u003eThis study shows that a small protein called humanin, produced inside mitochondria, helps protect eye cells responsible for vision from damage caused by oxidative stress. When extra humanin is added, it gets into the cells and helps keep their mitochondria healthy, prevents cell death and aging, and helps maintain the barrier functions of these cells. These findings suggest that humanin might be useful in developing treatments for age-related eye diseases like macular degeneration.\u003c\/p\u003e\n\u003cp class=\"MdParagraph\"\u003e \u003c\/p\u003e\n\u003cp class=\"MdParagraph\"\u003e\u003cspan\u003e⚠️ \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003eResearch Use Only:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e This product is intended for research purposes only. Not for human consumption. Not approved by the FDA. For use by qualified researchers only. Keep out of reach of children.\u003c\/span\u003e\u003c\/p\u003e","brand":"Biotech Peptides","offers":[{"title":"Default Title","offer_id":48069429887188,"sku":null,"price":165.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/6512\/5588\/files\/humanin20_2_10_wf03_720x-600x815-2.webp?v=1780886863","url":"https:\/\/biotech-peptides-5.myshopify.com\/products\/humanin-10mg-vials","provider":"Biotech Peptides","version":"1.0","type":"link"}